HOW BIG IS THE SOFT TISSUE REPAIR MARKET?

US$5bn MARKET OPPORTUNITY

Rotator Cuff TEAR

-       Leads to shoulder dysfunction and pain

-       4M patients US alone

-       600K annual surgeries US alone

-       $600M+ market opportunity

Meniscus Tear Repair

-       Painful, compromises knee function

-       1.2M surgeries annually US alone

-       $1B+ market opportunity

Cartilage Lesions Repair

-       Lesions cause friction and pain

-       1.2M detected lesions annually US alone

-       120K surgeries (lack of options)

-       $1B+ market opportunity

STANDARD OF CARE SURGERY HAS HIGH FAILURE RATE

HENCE THE STRONG NEED FOR MORE EFFECTIVE TREATMENTS

ORTHO-R® TECHNOLOGY – NEW PARADIGM

ORTHO-R EASY TO USE AND ADDS 8-10 MINUTES TO STANDARD OF CARE SURGERY

BENEFITS

-       Increases PRP residence time for faster & better tissue repair (from less than 24 hours for PRP alone to up to 6 weeks for Ortho-R product)

-       Keeps voluminous implant completely covering the surgically repaired site

-       Easy to use by orthopedic surgeons

-       Better mechanical and biological new tissue properties and faster recovery

-       Better tissue formation and integration between tendon and bone

-       Safe and gradual and sustain release of growth factors and cytokines from platelets

PRODUCT DEVELOPMENT PORTFOLIO

KEY VALUE MILESTONES

HANUMAN PRP SYSTEM GLOBAL LICENSING DEAL

-       Exclusive Global License to use, manufacture, sublicense and sell Product in combination with ORTHO-R

-       Fields: Tendons, Ligaments, Meniscus, Cartilage and Wound Healing (non-exclusive)

-       Royalty to Hanuman on net sales (on Product)

-       New product addition to ORTHO RTI portfolio

-       Generates significant revenues to ORTHO RTI in surplus of ORTHO R product

-       Perfect complementarity / integration to ORTHO-R

WORLD CLASS PARTNERSHIPS AND COLLABORATORS