And regarding requiring an a priori hypothesis and prior evidence for Rosuvastatin vs Atorvastatin , I was pretty sure I remembered after the study Don saying it didn't even occur to them that rosuvastatin and atorvastatin would be different. 

Just found it.....

Slide 3

"....And we had the very surprised but pleasant response of Rosuvastatin, or Crestor as it’s also known, has a very positive impact when in combination with RVX- 208...."

Slide 8

"....Once again, the low HDL Rosuvastatin patients far exceed the Atorvastatin patients. We were able to take advantage of this unexpected finding by filing patent protection for a future six dose combination involving RVX-208 and Rosuvastatin...."

(My bolding.)

https://agoracom.com/ir/Resverlogix/forums/off-topic/topics/601276-resverlogix-webcast-feb-12-2014/?message_id=1886354