Don't think this has been shared yet:

https://www.healio.com/cardiology/chd-prevention/news/online/%7Bf6f0a7b8-a3cb-4d95-9846-78ce98ff3838%7D/apabetalone-fails-to-benefit-mace-but-cautious-optimism-remains

And here's a snippet, a quote attributed to Dr. Ray:

The compelling signals for a large treatment effect suggest a trial of between 4,000 and 5,000 people with 400 to 500 events in a similar population would be adequately powered to test this approach in reducing CVD. A follow-up study is now needed.