"In discussion of the high / low LDL group responses there is no mention ( at least I haven"t noticed ) of HDL levels and its ratio. Would that have any possible effect?"
Possibly. In slide 19 one can see that there were more events in those w/ below median HDL compared to above median HDL. It didn't reach statistical significance; however, apabetalone elicited a 26% RRR in the below median HDL group and only a 5% RRR in the above median HDL group. These were all low HDL patients, but apparently the very low benefited more from apabetalone.