I was looking through the BETonMACE Cognitive Assessment study. I noticed that the group that showed the most improvement (MoCA < 22 at baseline) also had a relatively high level of High Sensitivity C Reactive Protein (hsCRP) (4.4 mg/L (3.0-10.0). Question: is there a correlation between high hsCRP and lower kidney function (eGFR)? Or, has this already been addressed in previous posts?
I know that the MoCA <22 cohort showed the greatest improvement, and they also had the lowest overall eGFR at baseline. I'm just trying to get a handle on the possible cause for the MoCA improvement: improved kidney function due to apabetalone; or improved (lowered) hsCRP due to apabetalone.