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Message: Covid and apabetalone

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From all drugs found here as candidate to be repurposed for treating multiorgan damages produced by COVID-19, romidepsin and apabetalone (we exclude here ellagic acid, which is a natural product) are the ones acting over a larger number of organs/systems damaged by COVID-19. Apabetalone has been previously identified as a potential drug for targeting inflammation and cytokine storm in COVID-19 [86,87]. Such identification has been based on the fact that it inhibits expression of genes related to vascular inflammation via the suppression of BET-mediated transcription. The last are triggered by multiple pro-inflammatory stimuli, such as the ones occurring in COVID-19. The same works pointed out that the inhibition of BRD4 could be considered as a potential route to ameliorate hyperinflammation and cytokine storm produced by this disease.

 

 

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