"In theory though it does make sense that aducanumab would produce less brain swelling in combination with apabetalone as we already know that ABL reduces inflammation. But does it do it in the brain. Do any of the science people on the board remember if inflammation in the brain was reduced in the BoM trial?"
tada, wouldn't ABL need to cross the BBB to be effective in reducing inflammation in the brain?
Bear did state the following in a previous posting.
"Thus far, there has been scant evidence that apabetalone gets across the blood brain barrier and into the brain/central nervous system."
Koo
