CALGARY, Alberta, March 17, 2022 (GLOBE NEWSWIRE) -- Resverlogix Corp. ("Resverlogix") (TSX:RVX) today announced the publication of an article entitled “BET Protein Inhibition for Pulmonary Arterial Hypertension: A Pilot Clinical Study” in the prestigious American Journal of Respiratory and Critical Care Medicine – which has an impact factor of 21.4. The article outlines the positive impact of apabetalone in the investigator-led pulmonary arterial hypertension (PAH) pilot study, APPRoAcH-p.

The article can be found HERE

“The encouraging results published today highlight the potential benefit of BET protein inhibition, such as Resverlogix’s apabetalone, as a therapeutic strategy for PAH,” said Dr. Steeve Provencher, Director of Pulmonary Research, Quebec Heart and Lung Institute, Laval University, and the lead author of the article. “We are excited to be moving forward with a larger trial of apabetalone in PAH patients.”

Publication Highlights Include:

All patients completed the 16-week trial without discontinuation or dose reduction, suggesting that apabetalone was well tolerated in the study population

Patients treated with apabetalone exhibited a reduction in pulmonary vascular resistance (PVR) at 16 weeks, the key exploratory efficacy endpoint of the study

Apabetalone treatment was also associated with improved cardiac output (CO) and stroke volume (SV) over the 16-week treatment course

“The APPRoAcH pilot study showed the potential benefit that apabetalone can offer for PAH patients,” said Donald J. McCaffrey, President & CEO of Resverlogix. “We are thrilled to be working with Dr. Provencher, and his colleagues at the Quebec Heart and Lung Institute, to help bring this life-saving treatment to market. We also want to recognize the important contribution of the IUCPQ Foundation to this work.”

A primer on outcome measures used in this trial can be found HERE.

A summary of the APPRoAcH-p trial design can be found HERE

Next Steps:

Full trial results will be presented at an upcoming scientific meeting (to be determined). The encouraging results of this study pave the way for the larger multi-centered APPRoAcH-2 trial, which is expected to begin enrolling patients later this year, and will be a phase 2, randomized, placebo-controlled study of apabetalone for the treatment of PAH.