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Zenith's BET Inhibitor ZEN-3694 is Currently Being Evaluated in Multiple Oncology Clinical Trials

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Message: Zenith Epigenetics Announces Collaboration with NCI in Developing ZEN-3694 for Multiple Oncology Indications

Zenith Epigenetics Announces Collaboration with NCI in Developing ZEN-3694 for Multiple Oncology Indications

posted on Oct 05, 2020 08:24AM

Zenith Epigenetics Announces Collaboration with NCI in Developing ZEN-3694 for Multiple Oncology Indications

First Clinical Study to Combine ZEN-3694 with BMS’s Immune Checkpoint Inhibitors nivolumab and ipilimumab for Treatment of Ovarian Cancer

https://www.zenithepigenetics.com/newsroom/news-releases?article=41

CALGARY, Alberta, Oct. 05, 2020 (GLOBE NEWSWIRE) -- Zenith Epigenetics Ltd. (“Zenith” or the “Company”) announced today the execution of a cooperative research and development agreement (CRADA) with the National Cancer Institute (NCI) to develop ZEN-3694 for multiple oncology indications. For the first clinical study under the CRADA, NCI is co-collaborating with Zenith and Bristol Myers Squibb (BMS) to investigate the combination of Zenith’s epigenetic therapy – BET inhibitor ZEN-3694 – with immuno-oncology therapies – checkpoint inhibitors nivolumab and ipilimumab – in resistant ovarian cancer.

“This significant research and development agreement allows us to leverage the combined resources of the NCI, Zenith, and other pharmaceutical companies to develop ZEN-3694 in multiple oncology indications with significant unmet need,” said Donald McCaffrey, President and CEO of Zenith. “NCI’s interest validates our belief that ZEN-3694 is a leading and differentiated BET inhibitor.

“Our therapy has proven to be safe and effective in prostate and breast cancer treatment and is combinable with multiple targeted agents. This collaboration will significantly supplement our efforts in expanding the portfolio of indications for ZEN-3694 both as a single agent and as a component of novel combination regimens with other therapies. We expect to announce other novel clinical trials including molecular pre-selection concepts in collaboration with the NCI in the upcoming months based on the high level of interest from leading key opinion leaders and clinical researchers.”

About Zenith

Zenith Capital Corp. is a biotechnology investment company originally spun out of Resverlogix Corp. (TSX: RVX) in 2013. Zenith Epigenetics Ltd., a wholly-owned subsidiary of Zenith Capital Corp., is a clinical stage biotechnology company focused on the discovery and development of novel therapeutics for the treatment of cancer and other disorders with significant unmet medical need. Zenith Epigenetics is developing various novel combinations of BET inhibitors with other targeted agents. The lead compound, ZEN-3694, is in clinical development for:

  1. Metastatic Castration Resistant Prostate Cancer (“mCRPC”) in combination with androgen receptor inhibitor, XTANDI

  2. Triple Negative Breast Cancer in combination with the PARP inhibitor TALZENNA with Pfizer as a collaborator

  3. Androgen receptor independent mCRPC in combination with immune checkpoint inhibitor Keytruda and XTANDI

For further information, please contact:

Investor Relations & Communications                       
Zenith Epigenetics
Phone: 587-390-7865
Email: [email protected]         
Website: www.zenithepigenetics.com

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