https://endpts.com/merck-halts-prostate-cancer-study-while-reporting-positive-readout-in-biliary-tract-cancer/

Don mentioned Merck had not had much luck with Keytruda in treating Prostate cancer and they hoped to double and triple up with Enzalutamide and Enzalutamide and Zen-3694 for better results.

Well Merck just announced their PIII trial with Keytruda and Enzalutamide has been halted early.  Let's hope the triple combo of Keytruda - Enzalutamide - ZEN-3694 has more success.

"Merck is slamming the brakes on a late-stage Keytruda study in prostate cancer after an interim analysis showed no improvement in survival, the company announced on Wednesday. However, the pharma giant cushioned the blow with a positive look at a separate study in biliary tract cancer.

An independent data monitoring committee reviewing the Phase III KEYNOTE-991 trial saw no improvement in overall survival or radiographic progression-free survival in a Keytruda combination group compared to the control group, Merck said in a news release. The trial was conducted in more than 1,200 patients with metastatic hormone-sensitive prostate cancer (mHSPC), or those whose cancer is controlled by keeping testosterone levels as low as would be expected after castration.

Researchers paired Keytruda with enzalutamide, sold by Astellas and Pfizer under the brand name Xtandi, and androgen deprivation therapy (ADT), while control patients received a placebo in combination with enzalutamide and ADT. The study wasn’t slated for completion until 2026, according to a federal register of clinical trials."