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Message: Re: Another RVX-208 Poster at IAS 2015 May 26

JK asked "IS THIS A POSITIVE STUDY FOR RVX-208 USE IN PRE- DIABETICS? IF SO WOULD A LONGER STUDY BEEN MORE SIGNIFICANT."

Please refer to the July 24, 2014 press release (http://www.resverlogix.com/media/press-release.html?id=505#.VV9CCllVhHw) in this paragraph:

"While the analyses of ASSURE data was being conducted, a new trial looking at metabolic parameters was in progress conducted at the Baker IDI Heart and Diabetes Institute (Melbourne, Australia). The investigators postulated that the RVX-208 induced rise in ApoA-I/HDL-C may impact pancreatic insulin secretion and thereby lower blood glucose (detected using an oral glucose tolerance test). Patients (n=23) with pre-diabetes mellitus (also called metabolic syndrome) were enrolled in the study and given 200 mg/day RVX-208 for a short duration of only 4 weeks. The preliminary results were not consistent with their hypothesis. However, this finding was useful in understanding the ASSURE data because for RVX-208 to reduce blood glucose in patients with DM required at least 12 weeks of treatment. Analysis of data from the new trial beyond preliminary results reported here will include; HDL abundance, lipidomics, platelet aggregation, monocyte activation and neutrophil adhesion. Resverlogix is planning to submit the above important findings and other new data to scientific journals for peer review prior to publication and presentation at leading medical conferences."

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