,,,possibly Koo,,,,,,,,,,,,,,I am not brainy enuff to figure that out,,,,,,progressing thru expensive trials in new cutting edge science which are double blinded is said to be the proper design of such,,,,but maybe the overall data is what is the most important aspect of such a trial,,and not just the top line data,,,or maybe only upon the addition of all data from the sites world wide could TLD be computed,,,,,it is an opinion but if the Assure trial is any indication it is very possible the oral pill was never even taken by a certain percentage of the test group,,,was there a check for the presence of the drug after dosing?,,,,,