Interesting to note that a Science publication re-inforces what Resverlogix has claimed all along, BD2 specific inhibitors have an effect in inflammatory and autoimmune diseases (I highlighted the text below). As such, this this not new, but nice to see that the notion is gaining traction in the most prestigious journals.

https://science.sciencemag.org/content/early/2020/03/18/science.aaz8455

Abstract

The two tandem bromodomains of the BET proteins enable chromatin binding to facilitate transcription. Drugs that inhibit both bromodomains equally have shown efficacy in certain malignant and inflammatory conditions. To explore the individual functional contributions of the first (BD1) and second (BD2) bromodomains in biology and therapy, we developed selective BD1 and BD2 inhibitors. We found that steady-state gene expression primarily requires BD1 whereas the rapid increase of gene expression induced by inflammatory stimuli requires both BD1 and BD2 of all BET proteins. BD1 inhibitors phenocopied the effects of pan-BET inhibitors in cancer models whereas BD2 inhibitors were predominantly effective in models of inflammatory and autoimmune disease. These insights into the differential requirement of BD1 and BD2 for the maintenance and induction of gene expression may guide future BET targeted therapies.