,,,,hummmm,,,this board is reading like a gossip column,,,,shareholders big and small will sell and buy these shares with cause and effect and reasoning that is none of our business,,,,,,so big holders sell for various reasons,,,,,small shareholders for various reasons as well,,,,,,,,,all of which most likely has nothing to do with the science,,,,,,,one has to understand what drives share price in the time frame which is impoertant to the holder or sideliner,,,,its just regular market dynamics,,,,,nothing to be fearful of.....jmo