From the discussion of the new paper: "Here we show that apabetalone is a BD2-selective BETi in live cells at concentrations below 15 μM. Thus, in the clinic apabetalone acts as a BD2-selective BETi; a single 100 mg dose results in a maximum plasma concentration of ~1 μM (360 ng/mL) in healthy volunteers and patients with renal impairment (stage 4 or 5 CKD) [83]."

BDAZ